Description
Product Characteristics:
In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-ARNT 3 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of Drosophila PER. PER, in concert with the product of the mammalian timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL 1 transactivation complex.
Subcellular location: Cytoplasm, Nucleus
Synonyms: Circadian clock protein PERIOD 1, Circadian clock protein PERIOD1, Circadian pacemaker protein Rigui, hPER 1, hPER, hPER1, KIAA0482, MGC88021, PER 1, PER, PER1, PER1 protein, PER1_HUMAN, Period 1, Period circadian protein homolog 1, Period drosophila homolog of, Period homolog 1, Period1, RIGUI.
Target Information: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. Alternative splicing has been observed in this gene\, however, these variants have not been fully described. [provided by RefSeq, Jul 2008]